SYNTHESIS, CHARACTERIZATION & ANALGESIC ACTIVITY OF IMIDAZOLO-AZATIDINONE DERIVATIVES

Abstract

New series of 2-Azatidinone (4a-j) were synthesized, the synthesized the structure of these new derivative were confirmed using spectral methods. Starting from Imidazole We prepared by using Benzil, Aldehyde (Acetaldehyde) in Acetamide and Glacial acetic acid then treated with chloro methyl ethyl acetate then converted into hydrazide by using hydrazine hydrate, then schiff bases were synthesized using different aldehyde in ethanol.The synthesis of the designed compounds has been successfully achieved. Purity and characterization were confirmed by determination of physical properties (melting point, & Rf values) and 1H-NMR sp.