Parkinson Disease And Its Pharmacological Evaluation By In-Vivo Methodes

Abstract

Parkinson’s Diseases (PD) , which is the second most common neurodegenerative disorder characterized by the progressive degeneration of the structure and function of the central nervous system. Parkinson Disease characterized by progressive death of dopaminergic neurons is substantia nigra. Parkinson’s Diseases (PD) is commonly known to be a complex motor and non-motor multifocal neurodegenerative disorder. Parkinson’s Diseases shows the various symptoms like rigidity ,tremor, bradykinesia. Parkinson’s Diseases is the second most common illness, affecting 1% of those over the age of 55. Parkinson’s Diseases shows the imbalance between Inhibitory Dopamine and Excitatory Acetylcholine.