Catalytical Applications Of Tio2nanoparticles For Knoevenagel Condensation Between Barbituric Acid And Aromatic Aldehydes

Abstract

The TiO₂Nanoparticles as an efficient catalyst was used for the synthesis of 5-arylidine barbituric acid derivatives by condensation reaction of barbituric acid and various aromatic aldehydes at room temperature with high speed stirring. The present protocol especially favoured because it offers advantages of high yields, short reaction times, simplicity and easy workup. Moreover the catalyst is inexpensive, stable, can be recycled and reused for four cycles without loss of its activity.